5FBX

Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor

5FBX の概要

• エントリーDOI: 10.2210/pdb5fbx/pdb
• 分子名称: Bromodomain-containing protein 4, (3~{S})-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methyl-3-phenyl-3~{H}-isoindol-1-one (3 entities in total)
• 機能のキーワード: brg1-associated factor 180, baf180, transcription, chromatin remodeling
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15417.75

構造登録者

Tallant, C.,Clark, P.G.K.,Siejka, P.,Fedorov, O.,Nowak, R.,Srikannathasan, V.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Brennan, P.E.,Dixon, D.,Knapp, S. (登録日: 2015-12-14, 公開日: 2015-12-30, 最終更新日: 2024-01-10)

• 主引用文献: Tallant, C.,Clark, P.G.K.,Siejka, P.,Fedorov, O.,Nowak, R.,Srikannathasan, V.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Brennan, P.E.,Dixon, D.,Knapp, S.; Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor; To Be Published,

実験手法

X-RAY DIFFRACTION (1.85 Å)