5FA7

CTX-M-15 in complex with FPI-1523

5FA7 の概要

• エントリーDOI: 10.2210/pdb5fa7/pdb
• 関連するPDBエントリー: 5FAO 5FAP 5FAQ 5FAS 5FAT
• 分子名称: Beta-lactamase, [[(3~{R},6~{S})-6-(acetamidocarbamoyl)-1-methanoyl-piperidin-3-yl]amino] hydrogen sulfate (3 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57621.08

構造登録者

King, A.M.,King, D.T.,French, S.,Brouillette, E.,Asli, A.,Alexander, A.N.,Vuckovic, M.,Maiti, S.N.,Parr, T.R.,Brown, E.D.,Malouin, F.,Strynadka, N.C.J.,Wright, G.D. (登録日: 2015-12-11, 公開日: 2016-01-20, 最終更新日: 2019-11-20)

• 主引用文献: King, A.M.,King, D.T.,French, S.,Brouillette, E.,Asli, A.,Alexander, J.A.,Vuckovic, M.,Maiti, S.N.,Parr, T.R.,Brown, E.D.,Malouin, F.,Strynadka, N.C.,Wright, G.D.; Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-beta-Lactamases and Penicillin-Binding Proteins.; Acs Chem.Biol., 11:864-868, 2016; PubMed: 26731698; DOI: 10.1021/acschembio.5b00944

実験手法

X-RAY DIFFRACTION (1.67 Å)