5F4J

Protruding domain of GII.17 norovirus Saitama/T87

5F4J の概要

• エントリーDOI: 10.2210/pdb5f4j/pdb
• 分子名称: Protruding domain of GII.17 norovirus capsid, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: norovirus, virus capsid, protruding domain, viral protein
• 由来する生物種: Norovirus GII/Hu/JP/2002/GII.P16_GII.17/Saitama/T87
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33742.57

構造登録者

Singh, B.K.,Hansman, G.S. (登録日: 2015-12-03, 公開日: 2016-01-13, 最終更新日: 2024-01-10)

主引用文献

Singh, B.K.,Koromyslova, A.,Hefele, L.,Gurth, C.,Hansman, G.S.
Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.
J.Virol., 90:2710-2715, 2015

PubMed Abstract: Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.

PubMed: 26699640
DOI: 10.1128/JVI.03119-15

実験手法

X-RAY DIFFRACTION (1.933 Å)