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5F3C

Crystal structure of human KDM4A in complex with compound 52d

Summary for 5F3C
Entry DOI10.2210/pdb5f3c/pdb
DescriptorLysine-specific demethylase 4A, ZINC ION, 8-[4-[2-[(4-fluorophenyl)methyl-methyl-amino]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ... (7 entities in total)
Functional Keywordsepigenetics, demethylase, inhibitor, oxidoreductase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : O75164
Total number of polymer chains4
Total formula weight170442.36
Authors
Le Bihan, Y.-V.,Westwood, I.M.,van Montfort, R.L.M. (deposition date: 2015-12-02, release date: 2016-01-20, Last modification date: 2024-01-10)
Primary citationBavetsias, V.,Lanigan, R.M.,Ruda, G.F.,Atrash, B.,McLaughlin, M.G.,Tumber, A.,Mok, N.Y.,Le Bihan, Y.V.,Dempster, S.,Boxall, K.J.,Jeganathan, F.,Hatch, S.B.,Savitsky, P.,Velupillai, S.,Krojer, T.,England, K.S.,Sejberg, J.,Thai, C.,Donovan, A.,Pal, A.,Scozzafava, G.,Bennett, J.M.,Kawamura, A.,Johansson, C.,Szykowska, A.,Gileadi, C.,Burgess-Brown, N.A.,von Delft, F.,Oppermann, U.,Walters, Z.,Shipley, J.,Raynaud, F.I.,Westaway, S.M.,Prinjha, R.K.,Fedorov, O.,Burke, R.,Schofield, C.J.,Westwood, I.M.,Bountra, C.,Muller, S.,van Montfort, R.L.,Brennan, P.E.,Blagg, J.
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
J.Med.Chem., 59:1388-1409, 2016
Cited by
PubMed: 26741168
DOI: 10.1021/acs.jmedchem.5b01635
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.06 Å)
Structure validation

217705

数据于2024-03-27公开中

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