5F20

Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one

Summary for 5F20

Entry DOI	10.2210/pdb5f20/pdb
Related	5F1Z
Descriptor	Non-receptor tyrosine-protein kinase TYK2, 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one (3 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35165.21
Authors	Skene, R.J. (deposition date: 2015-12-01, release date: 2016-01-13, Last modification date: 2024-03-06)
Primary citation	Yogo, T.,Nagamiya, H.,Seto, M.,Sasaki, S.,Shih-Chung, H.,Ohba, Y.,Tokunaga, N.,Lee, G.N.,Rhim, C.Y.,Yoon, C.H.,Cho, S.Y.,Skene, R.,Yamamoto, S.,Satou, Y.,Kuno, M.,Miyazaki, T.,Nakagawa, H.,Okabe, A.,Marui, S.,Aso, K.,Yoshida, M. Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors. J.Med.Chem., 59:733-749, 2016 Cited by PubMed: 26701356 DOI: 10.1021/acs.jmedchem.5b01857 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.91 Å)

Structure validation