5F20

Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one

5F20 の概要

• エントリーDOI: 10.2210/pdb5f20/pdb
• 関連するPDBエントリー: 5F1Z
• 分子名称: Non-receptor tyrosine-protein kinase TYK2, 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one (3 entities in total)
• 機能のキーワード: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35165.21

構造登録者

Skene, R.J. (登録日: 2015-12-01, 公開日: 2016-01-13, 最終更新日: 2024-03-06)

• 主引用文献: Yogo, T.,Nagamiya, H.,Seto, M.,Sasaki, S.,Shih-Chung, H.,Ohba, Y.,Tokunaga, N.,Lee, G.N.,Rhim, C.Y.,Yoon, C.H.,Cho, S.Y.,Skene, R.,Yamamoto, S.,Satou, Y.,Kuno, M.,Miyazaki, T.,Nakagawa, H.,Okabe, A.,Marui, S.,Aso, K.,Yoshida, M.; Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors.; J.Med.Chem., 59:733-749, 2016; PubMed: 26701356; DOI: 10.1021/acs.jmedchem.5b01857

実験手法

X-RAY DIFFRACTION (2.91 Å)