5F1Z

Structure of TYK2 with inhibitor 16: 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one

Summary for 5F1Z

• Entry DOI: 10.2210/pdb5f1z/pdb
• Related: 5F20
• Descriptor: Non-receptor tyrosine-protein kinase TYK2, 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one (3 entities in total)
• Functional Keywords: kinase, complex, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 35203.30

Authors

Skene, R.J. (deposition date: 2015-12-01, release date: 2016-01-13, Last modification date: 2024-03-06)

• Primary citation: Yogo, T.,Nagamiya, H.,Seto, M.,Sasaki, S.,Shih-Chung, H.,Ohba, Y.,Tokunaga, N.,Lee, G.N.,Rhim, C.Y.,Yoon, C.H.,Cho, S.Y.,Skene, R.,Yamamoto, S.,Satou, Y.,Kuno, M.,Miyazaki, T.,Nakagawa, H.,Okabe, A.,Marui, S.,Aso, K.,Yoshida, M.; Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors.; J.Med.Chem., 59:733-749, 2016; PubMed: 26701356; DOI: 10.1021/acs.jmedchem.5b01857

Experimental method

X-RAY DIFFRACTION (2.65 Å)