5F1R

The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (C10)

Summary for 5F1R

• Entry DOI: 10.2210/pdb5f1r/pdb
• Related: 2BEO
• Descriptor: Listeriolysin regulatory protein, (3~{R})-8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid (3 entities in total)
• Functional Keywords: dna binding protein, prfa, 2-pyridones, virulence
• Biological source: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
• Total number of polymer chains: 2
• Total formula weight: 55413.69

Authors

Begum, A.,Grundstrom, C.,Good, J.A.D.,Andersson, C.,ALmqvist, F.,Johansson, J.,Sauer, U.H.,Sauer-Eriksson, A.E. (deposition date: 2015-11-30, release date: 2016-03-16, Last modification date: 2024-01-10)

• Primary citation: Good, J.A.,Andersson, C.,Hansen, S.,Wall, J.,Krishnan, K.S.,Begum, A.,Grundstrom, C.,Niemiec, M.S.,Vaitkevicius, K.,Chorell, E.,Wittung-Stafshede, P.,Sauer, U.H.,Sauer-Eriksson, A.E.,Almqvist, F.,Johansson, J.; Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.; Cell Chem Biol, 23:404-414, 2016; PubMed: 26991105; DOI: 10.1016/j.chembiol.2016.02.013

Experimental method

X-RAY DIFFRACTION (2.25 Å)