5F1N

MHC complexed to 11mer peptide

5F1N の概要

• エントリーDOI: 10.2210/pdb5f1n/pdb
• 関連するPDBエントリー: 5F1I
• 分子名称: MHC class I antigen, Beta-2-microglobulin, Peptide from Cytochrome P450 family 1 subfamily B polypeptide 1, ... (4 entities in total)
• 機能のキーワード: mhc, immune system
• 由来する生物種: Canis lupus familiaris (Dog); 詳細
• 細胞内の位置: Secreted : E2RN10
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 94401.23

構造登録者

Liu, J.,Chai, Y.,Qi, J.,Gao, G.F. (登録日: 2015-11-30, 公開日: 2016-11-30, 最終更新日: 2024-10-30)

主引用文献

Xiao, J.,Xiang, W.,Chai, Y.,Haywood, J.,Qi, J.,Ba, L.,Qi, P.,Wang, M.,Liu, J.,Gao, G.F.
Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I
J Immunol., 197:2306-2315, 2016

PubMed Abstract: Canines represent a crucial animal model for studying human diseases and organ transplantation, as well as the evolution of domestic animals. MHCs, with a central role in cellular immunity, are commonly used in the study of dog population genetics and genome evolution. However, the molecular basis for the peptide presentation of dog MHC remains largely unknown. In this study, peptide presentation by canine MHC class I DLA-88*50801 was structurally determined, revealing diversified anchoring modes of the binding peptides. Flexible and large pockets composed of both hydrophobic and hydrophilic residues can accommodate pathogen-derived peptides with diverse anchor residues, as confirmed by thermostability measurements. Furthermore, DLA-88*50801 contains an unusual α2 helix with a large coil in the TCR contact region. These results further our understanding of canine T cell immunity through peptide presentation of MHC class I and shed light on the molecular basis for vaccine development for canine infectious diseases, for example, canine distemper virus.

PubMed: 27511732
DOI: 10.4049/jimmunol.1600887

実験手法

X-RAY DIFFRACTION (2 Å)