5EZP

Human transthyretin (TTR) complexed with 4-hydroxy-chalcone

Summary for 5EZP

• Entry DOI: 10.2210/pdb5ezp/pdb
• Related: 4I89 4PM1 4PMF 4WNS 5AKS
• Descriptor: Transthyretin, 4-hydroxy-chalcone, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: human transthyretin (ttr), chalcone, inhibitor complex, new crystal polymorph, transport protein
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 8
• Total formula weight: 108094.82

Authors

Polsinelli, I.,Nencetti, S.,Shepard, W.E.,Orlandini, E.,Stura, E.A. (deposition date: 2015-11-26, release date: 2016-01-27, Last modification date: 2024-01-10)

• Primary citation: Polsinelli, I.,Nencetti, S.,Shepard, W.,Ciccone, L.,Orlandini, E.,Stura, E.A.; A new crystal form of human transthyretin obtained with a curcumin derived ligand.; J.Struct.Biol., 194:8-17, 2016; PubMed: 26796656; DOI: 10.1016/j.jsb.2016.01.007

Experimental method

X-RAY DIFFRACTION (2.5 Å)