5EW9
Crystal Structure of Aurora A Kinase Domain Bound to MK-5108
Summary for 5EW9
| Entry DOI | 10.2210/pdb5ew9/pdb |
| Descriptor | Aurora kinase A, 4-(3-chloranyl-2-fluoranyl-phenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid (3 entities in total) |
| Functional Keywords | transferase, protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 |
| Total number of polymer chains | 1 |
| Total formula weight | 31998.99 |
| Authors | Shiau, A.K.,Motamedi, A. (deposition date: 2015-11-20, release date: 2016-01-20, Last modification date: 2023-09-27) |
| Primary citation | de Groot, C.O.,Hsia, J.E.,Anzola, J.V.,Motamedi, A.,Yoon, M.,Wong, Y.L.,Jenkins, D.,Lee, H.J.,Martinez, M.B.,Davis, R.L.,Gahman, T.C.,Desai, A.,Shiau, A.K. A Cell Biologist's Field Guide to Aurora Kinase Inhibitors. Front Oncol, 5:285-285, 2015 Cited by PubMed: 26732741DOI: 10.3389/fonc.2015.00285 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.181 Å) |
Structure validation
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