5EVD

Crystal structure of the metallo-beta-lactamase L1 in complex with the bisthiazolidine inhibitor D-VC26

Summary for 5EVD

Entry DOI	10.2210/pdb5evd/pdb
Descriptor	Metallo-beta-lactamase L1, (3S,5S,7aR)-2,2-dimethyl-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, ZINC ION, ... (5 entities in total)
Functional Keywords	inhibitor, carbapenemase, antibiotic resistance, hydrolase
Biological source	Stenotrophomonas maltophilia (Pseudomonas maltophilia)
Cellular location	Periplasm : P52700
Total number of polymer chains	1
Total formula weight	29482.98
Authors	Hinchliffe, P.,Spencer, J. (deposition date: 2015-11-19, release date: 2016-06-01, Last modification date: 2024-01-10)
Primary citation	Hinchliffe, P.,Gonzalez, M.M.,Mojica, M.F.,Gonzalez, J.M.,Castillo, V.,Saiz, C.,Kosmopoulou, M.,Tooke, C.L.,Llarrull, L.I.,Mahler, G.,Bonomo, R.A.,Vila, A.J.,Spencer, J. Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes. Proc.Natl.Acad.Sci.USA, 113:E3745-E3754, 2016 Cited by PubMed: 27303030 DOI: 10.1073/pnas.1601368113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation