5EVA
Crystal structure of the human BRPF1 bromodomain in complex with SEED16
Summary for 5EVA
Entry DOI | 10.2210/pdb5eva/pdb |
Related | 5C7N |
Descriptor | Peregrin, ~{N}-[2,4-bis(fluoranyl)phenyl]-2-methyl-pyrazole-3-carboxamide, NITRATE ION, ... (4 entities in total) |
Functional Keywords | bromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P55201 |
Total number of polymer chains | 1 |
Total formula weight | 14002.91 |
Authors | Zhu, J.,Caflisch, A. (deposition date: 2015-11-19, release date: 2016-06-08, Last modification date: 2024-01-10) |
Primary citation | Zhu, J.,Caflisch, A. Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions. J.Med.Chem., 59:5555-5561, 2016 Cited by PubMed: 27167503DOI: 10.1021/acs.jmedchem.6b00215 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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