5EUC

The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase

5EUC の概要

• エントリーDOI: 10.2210/pdb5euc/pdb
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase (2 entities in total)
• 機能のキーワード: hprt, phosphoribosyltransferase, t. cruzi, quaternary structure, enzymatic activity modulation, stability, proteolysis, reversible oligomerization, disorder c-terminal region, bisphosphonates, transferase
• 由来する生物種: Trypanosoma cruzi (strain CL Brener)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 106666.24

構造登録者

Valsecchi, W.M.,Cousido-Siah, A.,Mitschler, A.,Podjarny, A.,Delfino, J.M.,Santos, J. (登録日: 2015-11-18, 公開日: 2016-03-30, 最終更新日: 2023-09-27)

• 主引用文献: Valsecchi, W.M.,Cousido-Siah, A.,Defelipe, L.A.,Mitschler, A.,Podjarny, A.,Santos, J.,Delfino, J.M.; The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase.; Biochim.Biophys.Acta, 1864:655-666, 2016; PubMed: 26969784; DOI: 10.1016/j.bbapap.2016.03.005

実験手法

X-RAY DIFFRACTION (2.65 Å)