5EU8

Structure of FIPV main protease in complex with dual inhibitors

Summary for 5EU8

• Entry DOI: 10.2210/pdb5eu8/pdb
• Related PRD ID: PRD_002214
• Descriptor: main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE, ZINC ION, ... (5 entities in total)
• Functional Keywords: fipv, main protease, dual inhibitors, zinc, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Feline infectious peritonitis virus (FIPV); More
• Total number of polymer chains: 2
• Total formula weight: 34305.15

Authors

Wang, F.,Chen, C.,Liu, X.,Yang, K.,Xu, X.,Yang, H. (deposition date: 2015-11-18, release date: 2015-12-30, Last modification date: 2023-11-15)

• Primary citation: Wang, F.,Chen, C.,Liu, X.,Yang, K.,Xu, X.,Yang, H.; Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors; J.Virol., 90:1910-1917, 2015; PubMed: 26656689; DOI: 10.1128/JVI.02685-15

Experimental method

X-RAY DIFFRACTION (2.447 Å)