5ETQ

S. aureus 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.96 angstrom resolution

5ETQ の概要

• エントリーDOI: 10.2210/pdb5etq/pdb
• 関連するPDBエントリー: 4M5H 5ETK 5ETL 5ETM 5ETN 5ETO 5ETP 5ETR 5ETS 5ETT 5ETV
• 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (6 entities in total)
• 機能のキーワード: inhibitor, complex, ampcpp, pyrophosphokinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38413.45

構造登録者

Dennis, M.L.,Peat, T.S.,Swarbrick, J.D. (登録日: 2015-11-18, 公開日: 2016-05-04, 最終更新日: 2023-11-15)

• 主引用文献: Dennis, M.L.,Pitcher, N.P.,Lee, M.D.,DeBono, A.J.,Wang, Z.C.,Harjani, J.R.,Rahmani, R.,Cleary, B.,Peat, T.S.,Baell, J.B.,Swarbrick, J.D.; Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli.; J.Med.Chem., 59:5248-5263, 2016; PubMed: 27094768; DOI: 10.1021/acs.jmedchem.6b00002

実験手法

X-RAY DIFFRACTION (1.96 Å)