5ESZ

Crystal Structure of Broadly Neutralizing Antibody CH04, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade AE Strain A244

5ESZ の概要

• エントリーDOI: 10.2210/pdb5esz/pdb
• 分子名称: CH04 Heavy Chain, CH04 Light Chain, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,Envelope glycoprotein gp160, ... (8 entities in total)
• 機能のキーワード: hiv-1, env, v1v2, ch0219, chavi, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 153403.10

構造登録者

Gorman, J.,Yang, M.,Kwong, P.D. (登録日: 2015-11-17, 公開日: 2015-12-16, 最終更新日: 2023-09-27)

• 主引用文献: Gorman, J.,Soto, C.,Yang, M.M.,Davenport, T.M.,Guttman, M.,Bailer, R.T.,Chambers, M.,Chuang, G.Y.,DeKosky, B.J.,Doria-Rose, N.A.,Druz, A.,Ernandes, M.J.,Georgiev, I.S.,Jarosinski, M.C.,Joyce, M.G.,Lemmin, T.M.,Leung, S.,Louder, M.K.,McDaniel, J.R.,Narpala, S.,Pancera, M.,Stuckey, J.,Wu, X.,Yang, Y.,Zhang, B.,Zhou, T.,Mullikin, J.C.,Baxa, U.,Georgiou, G.,McDermott, A.B.,Bonsignori, M.,Haynes, B.F.,Moore, P.L.,Morris, L.,Lee, K.K.,Shapiro, L.,Mascola, J.R.,Kwong, P.D.; Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design.; Nat. Struct. Mol. Biol., 23:81-90, 2016; PubMed: 26689967; DOI: 10.1038/nsmb.3144

実験手法

X-RAY DIFFRACTION (4.191 Å)