5ERY

Crystal Structure of APO MenD from M. tuberculosis - P212121

5ERY の概要

• エントリーDOI: 10.2210/pdb5ery/pdb
• 関連するPDBエントリー: 5ERX
• 分子名称: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (2 entities in total)
• 機能のキーワード: menaquinone biosynthesis, mend, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase, thiamin-diphosphate dependent enzyme, pyruvate oxidase family, transferase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 240275.78

構造登録者

Johnston, J.M.,Jirgis, E.N.M.,Bashiri, G.,Bulloch, E.M.M.,Baker, E.N. (登録日: 2015-11-16, 公開日: 2016-06-22, 最終更新日: 2024-03-06)

• 主引用文献: Jirgis, E.N.,Bashiri, G.,Bulloch, E.M.,Johnston, J.M.,Baker, E.N.; Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.; Structure, 24:1167-1177, 2016; PubMed: 27291649; DOI: 10.1016/j.str.2016.04.018

実験手法

X-RAY DIFFRACTION (2.25 Å)