5ER1
A rational approach to the design of antihypertensives. X-ray studies of complexes between aspartic proteinases and aminoalcohol renin inhibitors
Summary for 5ER1
Entry DOI | 10.2210/pdb5er1/pdb |
Related PRD ID | PRD_000308 |
Descriptor | ENDOTHIAPEPSIN, methyl N-[(2S,3S)-3-amino-2-hydroxy-5-methylhexyl]-L-valyl-L-isoleucyl-L-phenylalaninate (3 entities in total) |
Functional Keywords | acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Cryphonectria parasitica (chestnut blight fungus) |
Total number of polymer chains | 1 |
Total formula weight | 34334.56 |
Authors | Cooper, J.B.,Foundling, S.I.,Blundell, T.L. (deposition date: 1990-11-07, release date: 1991-01-15, Last modification date: 2017-11-29) |
Primary citation | Cooper, J.B.,Foundling, S.I.,Blundell, T.L.,Arrowsmith, R.J.,Harris, C.J.,Champness, J.N. A Rational Approach to the Design of Antihypertensives. X-Ray Studies of Complexes between Aspartic Proteinases and Aminoalcohol Renin Inhibitors Topics in Medicinal Chemistry, :308-, 1988 |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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