5EOL

Crystal structure of human Pim-1 kinase in complex with a macrocyclic quinoxaline-pyrrolodihydropiperidinone inhibitor

5EOL の概要

• エントリーDOI: 10.2210/pdb5eol/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, macrocyclic quinoxaline-pyrrolodihydropiperidinone, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: transferase, serine/threonine protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33608.03

構造登録者

Mohr, C. (登録日: 2015-11-10, 公開日: 2016-05-04, 最終更新日: 2024-03-06)

• 主引用文献: Cee, V.J.,Chavez, F.,Herberich, B.,Lanman, B.A.,Pettus, L.H.,Reed, A.B.,Wu, B.,Wurz, R.P.,Andrews, K.L.,Chen, J.,Hickman, D.,Laszlo, J.,Lee, M.R.,Guerrero, N.,Mattson, B.K.,Nguyen, Y.,Mohr, C.,Rex, K.,Sastri, C.E.,Wang, P.,Wu, Q.,Wu, T.,Xu, Y.,Zhou, Y.,Winston, J.T.,Lipford, J.R.,Tasker, A.S.,Wang, H.L.; Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.; Acs Med.Chem.Lett., 7:408-412, 2016; PubMed: 27096050; DOI: 10.1021/acsmedchemlett.5b00403

実験手法

X-RAY DIFFRACTION (2.2 Å)