5ENI
Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-13 N11537 (SGC - Diamond I04-1 fragment screening)
Summary for 5ENI
Entry DOI | 10.2210/pdb5eni/pdb |
Descriptor | PH-interacting protein, ~{N}-[[2,6-bis(chloranyl)phenyl]methyl]-2-oxidanyl-ethanamide (3 entities in total) |
Functional Keywords | bromodomain, phip, crystallographic fragment screen, structural genomics, structural genomics consortium, sgc, transcription, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15828.74 |
Authors | Krojer, T.,Talon, R.,Collins, P.,Bradley, A.,Cox, O.,Szykowska, A.,Burgess-Brown, N.,Brennan, P.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,von Delft, F.,Structural Genomics Consortium (SGC) (deposition date: 2015-11-09, release date: 2016-04-27, Last modification date: 2024-01-10) |
Primary citation | Cox, O.B.,Krojer, T.,Collins, P.,Monteiro, O.,Talon, R.,Bradley, A.,Fedorov, O.,Amin, J.,Marsden, B.D.,Spencer, J.,von Delft, F.,Brennan, P.E. A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7:2322-2330, 2016 Cited by PubMed: 29910922DOI: 10.1039/c5sc03115j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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