5EM7

EGFR kinase domain mutant "TMLR" with pyridone compound 13: 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide

5EM7 の概要

• エントリーDOI: 10.2210/pdb5em7/pdb
• 関連するPDBエントリー: 5EM5 5EM6 5EM8
• 分子名称: Epidermal growth factor receptor, SULFATE ION, 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide (3 entities in total)
• 機能のキーワード: protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38078.96

構造登録者

Eigenbrot, C.,Yu, C. (登録日: 2015-11-05, 公開日: 2015-12-30, 最終更新日: 2024-03-06)

• 主引用文献: Bryan, M.C.,Burdick, D.J.,Chan, B.K.,Chen, Y.,Clausen, S.,Dotson, J.,Eigenbrot, C.,Elliott, R.,Hanan, E.J.,Heald, R.,Jackson, P.,La, H.,Lainchbury, M.,Malek, S.,Mann, S.E.,Purkey, H.E.,Schaefer, G.,Schmidt, S.,Seward, E.,Sideris, S.,Wang, S.,Yen, I.,Yu, C.,Heffron, T.P.; Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.; Acs Med.Chem.Lett., 7:100-104, 2016; PubMed: 26819674; DOI: 10.1021/acsmedchemlett.5b00428

実験手法

X-RAY DIFFRACTION (2.81 Å)