5EK2

Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with NLG919 analogue

5EK2 の概要

• エントリーDOI: 10.2210/pdb5ek2/pdb
• 関連するPDBエントリー: 5EK3 5EK4
• 分子名称: Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 1-cyclohexyl-2-[(5~{S})-6-fluoranyl-5~{H}-imidazo[1,5-b]isoindol-5-yl]ethanone, ... (4 entities in total)
• 機能のキーワード: inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 92598.11

構造登録者

Peng, Y.H.,Wu, J.S.,Wu, S.Y. (登録日: 2015-11-03, 公開日: 2015-12-23, 最終更新日: 2023-11-08)

• 主引用文献: Peng, Y.H.,Ueng, S.H.,Tseng, C.T.,Hung, M.S.,Song, J.S.,Wu, J.S.,Liao, F.Y.,Fan, Y.S.,Wu, M.H.,Hsiao, W.C.,Hsueh, C.C.,Lin, S.Y.,Cheng, C.Y.,Tu, C.H.,Lee, L.C.,Cheng, M.F.,Shia, K.S.,Shih, C.,Wu, S.Y.; Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1; J.Med.Chem., 59:282-293, 2016; PubMed: 26642377; DOI: 10.1021/acs.jmedchem.5b01390

実験手法

X-RAY DIFFRACTION (2.68 Å)