5EHR

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP099

5EHR の概要

• エントリーDOI: 10.2210/pdb5ehr/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 11, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: phosphatase ptp inhibitor ptpn11 allosteric, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q06124
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121944.42

構造登録者

Stams, T.,Fodor, M. (登録日: 2015-10-28, 公開日: 2016-06-29, 最終更新日: 2023-09-27)

• 主引用文献: Chen, Y.P.,LaMarche, M.J.,Chan, H.M.,Fekkes, P.,Garcia-Fortanet, J.,Acker, M.G.,Antonakos, B.,Chen, C.H.,Chen, Z.,Cooke, V.G.,Dobson, J.R.,Deng, Z.,Fei, F.,Firestone, B.,Fodor, M.,Fridrich, C.,Gao, H.,Grunenfelder, D.,Hao, H.X.,Jacob, J.,Ho, S.,Hsiao, K.,Kang, Z.B.,Karki, R.,Kato, M.,Larrow, J.,La Bonte, L.R.,Lenoir, F.,Liu, G.,Liu, S.,Majumdar, D.,Meyer, M.J.,Palermo, M.,Perez, L.,Pu, M.,Price, E.,Quinn, C.,Shakya, S.,Shultz, M.D.,Slisz, J.,Venkatesan, K.,Wang, P.,Warmuth, M.,Williams, S.,Yang, G.,Yuan, J.,Zhang, J.H.,Zhu, P.,Ramsey, T.,Keen, N.J.,Sellers, W.R.,Stams, T.,Fortin, P.D.; Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.; Nature, 535:148-152, 2016; PubMed: 27362227; DOI: 10.1038/nature18621

実験手法

X-RAY DIFFRACTION (1.7 Å)