5EGG

Crystal structure of human ubiquitin-conjugating enzyme UBCH5C

5EGG の概要

• エントリーDOI: 10.2210/pdb5egg/pdb
• 分子名称: Ubiquitin-conjugating enzyme E2 D3 (2 entities in total)
• 機能のキーワード: biquitin-conjugating enzyme, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Peripheral membrane protein : P61077
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17780.32

構造登録者

Zhu, L.,Li, H.,Wu, F.,Zhu, J. (登録日: 2015-10-27, 公開日: 2016-11-02, 最終更新日: 2023-11-08)

主引用文献

Wu, F.,Zhu, J.,Li, H.,Zhu, L.
Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c
Acta Pharm Sin B, 7:390-394, 2017

PubMed Abstract: UbcH5c belongs to the ubiquitin-conjugating enzyme family and plays an important role in catalyzing ubiquitination during TNF---triggered NF-B activation. Therefore, UbcH5c is a potent therapeutic target for the treatment of inflammatory and autoimmune diseases induced by aberrant activation of NF-B. In this study, we established a stable expression system for recombinant UbcH5c and solved the crystal structure of UbcH5c belonging to space group P222 with one molecule in the asymmetric unit. This study provides the basis for further study of UbcH5c including the design of UbcH5c inhibitors.

PubMed: 28540177
DOI: 10.1016/j.apsb.2016.12.008

実験手法

X-RAY DIFFRACTION (1.76 Å)