5EGA

2009 H1N1 PA endonuclease domain in complex with an N-acylhydrazone inhibitor

Summary for 5EGA

• Entry DOI: 10.2210/pdb5ega/pdb
• Related: 5DES
• Descriptor: Polymerase acidic protein, MANGANESE (II) ION, 3,4,5-tris(oxidanyl)-~{N}-[(~{E})-[3,4,5-tris(oxidanyl)phenyl]methylideneamino]benzamide, ... (4 entities in total)
• Functional Keywords: influenza, endonuclease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus; More
• Total number of polymer chains: 1
• Total formula weight: 22400.29

Authors

Kumar, G.,White, S.W. (deposition date: 2015-10-26, release date: 2016-08-31, Last modification date: 2023-09-27)

• Primary citation: Carcelli, M.,Rogolino, D.,Gatti, A.,De Luca, L.,Sechi, M.,Kumar, G.,White, S.W.,Stevaert, A.,Naesens, L.; N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes.; Sci Rep, 6:31500-31500, 2016; PubMed: 27510745; DOI: 10.1038/srep31500

Experimental method

X-RAY DIFFRACTION (2.15 Å)