5EEH

Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 2-chloro-4-nitrophenol

5EEH の概要

• エントリーDOI: 10.2210/pdb5eeh/pdb
• 関連するPDBエントリー: 5EEG
• 分子名称: Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, 2-chloranyl-4-nitro-phenol, ... (5 entities in total)
• 機能のキーワード: unnatural substrate, structural genomics, psi-biology, protein structure initiative, enzyme discovery for natural product biosynthesis, natpro, transferase
• 由来する生物種: Streptomyces peucetius
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 127622.33

構造登録者

Wang, F.,Singh, S.,Thorson, J.S.,Phillips Jr., G.N.,Enzyme Discovery for Natural Product Biosynthesis (NatPro) (登録日: 2015-10-22, 公開日: 2015-12-16, 最終更新日: 2023-09-27)

• 主引用文献: Huber, T.D.,Wang, F.,Singh, S.,Johnson, B.R.,Zhang, J.,Sunkara, M.,Van Lanen, S.G.,Morris, A.J.,Phillips, G.N.,Thorson, J.S.; Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways.; Acs Chem.Biol., 11:2484-2491, 2016; PubMed: 27351335; DOI: 10.1021/acschembio.6b00348

実験手法

X-RAY DIFFRACTION (1.82 Å)