5EC9

Retinoic acid receptor alpha in complex with chiral dihydrobenzofuran benzoic acid 9a and a fragment of the coactivator TIF2

5EC9 の概要

• エントリーDOI: 10.2210/pdb5ec9/pdb
• 分子名称: Retinoic acid receptor RXR-alpha, LYS-HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, 4-[(11S,15R)-4,4,7,7-Tetramethyl-16-oxatetracyclo[8.6.0.03,8.011,15]hexadeca-1(10),2,8-trien-11-yl]benzoic acid, ... (4 entities in total)
• 機能のキーワード: transcription, nuclear receptor, agonist
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : P19793
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25460.84

構造登録者

Leysen, S.,Ottmann, C.,Schafer, A.,Scheepstra, M.,Brunsveld, L.,Sunden, R.,Ma, J.N.,Burnstein, E.S.,Olsson, R. (登録日: 2015-10-20, 公開日: 2016-03-09, 最終更新日: 2024-06-19)

• 主引用文献: Sunden, H.,Schafer, A.,Scheepstra, M.,Leysen, S.,Malo, M.,Ma, J.N.,Burstein, E.S.,Ottmann, C.,Brunsveld, L.,Olsson, R.; Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.; J.Med.Chem., 59:1232-1238, 2016; PubMed: 26820900; DOI: 10.1021/acs.jmedchem.5b01702

実験手法

X-RAY DIFFRACTION (2.3 Å)