5EBT
Tankyrase 1 with Phthalazinone 2
Summary for 5EBT
Entry DOI | 10.2210/pdb5ebt/pdb |
Descriptor | Tankyrase-1, (R,R)-2,3-BUTANEDIOL, 4-[bis(fluoranyl)-[3-[[(6~{S})-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one, ... (5 entities in total) |
Functional Keywords | tankyrase, parp, centrosome clustering, oncology, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: O95271 |
Total number of polymer chains | 4 |
Total formula weight | 99021.25 |
Authors | Kazmirski, S.L.,Johannes, J. (deposition date: 2015-10-19, release date: 2016-03-02, Last modification date: 2024-03-06) |
Primary citation | Johannes, J.W.,Almeida, L.,Daly, K.,Ferguson, A.D.,Grosskurth, S.E.,Guan, H.,Howard, T.,Ioannidis, S.,Kazmirski, S.,Lamb, M.L.,Larsen, N.A.,Lyne, P.D.,Mikule, K.,Ogoe, C.,Peng, B.,Petteruti, P.,Read, J.A.,Su, N.,Sylvester, M.,Throner, S.,Wang, W.,Wang, X.,Wu, J.,Ye, Q.,Yu, Y.,Zheng, X.,Scott, D.A. Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Bioorg.Med.Chem.Lett., 25:5743-5747, 2015 Cited by PubMed: 26546219DOI: 10.1016/j.bmcl.2015.10.079 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
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