5EAR

Crystal structure of human WDR5 in complex with compound 9d

5EAR の概要

• エントリーDOI: 10.2210/pdb5ear/pdb
• 関連するPDBエントリー: 5EAL 5EAM 5EAP
• 分子名称: WD repeat-containing protein 5, N-[5-(2,3-dihydro-1-benzofuran-7-yl)-2-(4-methylpiperazin-1-yl)phenyl]-3-methylbenzamide, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: wdr5, compound 9d, structural genomics, structural genomics consortium, sgc, transcription - transcription inhibitor complex, transcription / transcription inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P61964
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70710.21

構造登録者

DONG, A.,DOMBROVSKI, L.,SMIL, D.,GETLIK, M.,BOLSHAN, Y.,WALKER, J.R.,SENISTERRA, G.,PODA, G.,AL-AWAR, R.,SCHAPIRA, M.,VEDADI, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,BROWN, P.J.,WU, H.,Structural Genomics Consortium (SGC) (登録日: 2015-10-16, 公開日: 2015-11-04, 最終更新日: 2023-09-27)

• 主引用文献: Getlik, M.,Smil, D.,Zepeda-Velazquez, C.,Bolshan, Y.,Poda, G.,Wu, H.,Dong, A.,Kuznetsova, E.,Marcellus, R.,Senisterra, G.,Dombrovski, L.,Hajian, T.,Kiyota, T.,Schapira, M.,Arrowsmith, C.H.,Brown, P.J.,Vedadi, M.,Al-Awar, R.; Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).; J. Med. Chem., 59:2478-2496, 2016; PubMed: 26958703; DOI: 10.1021/acs.jmedchem.5b01630

実験手法

X-RAY DIFFRACTION (1.8 Å)