5EAK
Optimization of Microtubule Affinity Regulating Kinase (MARK) Inhibitors with Improved Physical Properties
Summary for 5EAK
Entry DOI | 10.2210/pdb5eak/pdb |
Descriptor | Serine/threonine-protein kinase MARK2, N-[(1S,2R)-2-aminocyclohexyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide (3 entities in total) |
Functional Keywords | catalytic domain, protein-serine-threonine kinases, kinase inhibitor, serine-threonine kinases, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Peripheral membrane protein: Q7KZI7 |
Total number of polymer chains | 2 |
Total formula weight | 76508.48 |
Authors | Su, H.P. (deposition date: 2015-10-16, release date: 2016-02-17, Last modification date: 2024-03-06) |
Primary citation | Sloman, D.L.,Noucti, N.,Altman, M.D.,Chen, D.,Mislak, A.C.,Szewczak, A.,Hayashi, M.,Warren, L.,Dellovade, T.,Wu, Z.,Marcus, J.,Walker, D.,Su, H.P.,Edavettal, S.C.,Munshi, S.,Hutton, M.,Nuthall, H.,Stanton, M.G. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg.Med.Chem.Lett., 26:4362-4366, 2016 Cited by PubMed: 27491711DOI: 10.1016/j.bmcl.2016.02.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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