5E9Q

DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND MOLECULE BF174

5E9Q の概要

• エントリーDOI: 10.2210/pdb5e9q/pdb
• 分子名称: Genome polyprotein, S-ADENOSYLMETHIONINE, 2-({[2-amino-4-(trifluoromethyl)phenyl]carbamoyl}amino)-4-methylbenzoic acid, ... (4 entities in total)
• 機能のキーワード: transferase, dengue virus, ns5 methyltransferase, fragment-based drug discovery
• 由来する生物種: Dengue virus 3 (DENV-3)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59491.51

構造登録者

Barral, K.,Bricogne, G.,Sharff, A. (登録日: 2015-10-15, 公開日: 2016-10-26, 最終更新日: 2024-01-10)

• 主引用文献: Benmansour, F.,Trist, I.,Coutard, B.,Decroly, E.,Querat, G.,Brancale, A.,Barral, K.; Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.; Eur.J.Med.Chem., 125:865-880, 2016; PubMed: 27750202; DOI: 10.1016/j.ejmech.2016.10.007

実験手法

X-RAY DIFFRACTION (1.79 Å)