5E7N

Crystal Structure of RPA70N in complex with VU0085636

Summary for 5E7N

DescriptorReplication protein A 70 kDa DNA-binding subunit, 2-({3-[(4-bromophenyl)sulfamoyl]-4-methylbenzoyl}amino)benzoic acid (3 entities in total)
Functional Keywordsinhibitor, complex, protein binding-inhibitor complex, protein binding/inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  P27694
Total number of polymer chains1
Total molecular weight13987.07
Authors
Primary citation
Patrone, J.D.,Pelz, N.F.,Bates, B.S.,Souza-Fagundes, E.M.,Vangamudi, B.,Camper, D.V.,Kuznetsov, A.G.,Browning, C.F.,Feldkamp, M.D.,Frank, A.O.,Gilston, B.A.,Olejniczak, E.T.,Rossanese, O.W.,Waterson, A.G.,Chazin, W.J.,Fesik, S.W.
Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A.
Chemmedchem, 11:893-899, 2016
PubMed: 26748787 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.201500479
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.21 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2176009.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5e7n
no rotation
Molmil generated image of 5e7n
rotated about x axis by 90°
Molmil generated image of 5e7n
rotated about y axis by 90°