5E7N

Crystal Structure of RPA70N in complex with VU0085636

5E7N の概要

• エントリーDOI: 10.2210/pdb5e7n/pdb
• 分子名称: Replication protein A 70 kDa DNA-binding subunit, 2-({3-[(4-bromophenyl)sulfamoyl]-4-methylbenzoyl}amino)benzoic acid (3 entities in total)
• 機能のキーワード: inhibitor, complex, protein binding-inhibitor complex, protein binding/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13987.07

構造登録者

Gilston, B.A.,Patrone, J.D.,Pelz, N.F.,Bates, B.S.,Souza-Fagundes, E.M.,Vangamudi, B.,Camper, D.,Kuznetsov, A.,Browning, C.F.,Feldkamp, M.D.,Olejniczak, E.T.,Rossanese, O.W.,Waterson, A.G.,Fesik, S.W.,Chazin, W.J. (登録日: 2015-10-12, 公開日: 2016-01-27, 最終更新日: 2023-09-27)

• 主引用文献: Patrone, J.D.,Pelz, N.F.,Bates, B.S.,Souza-Fagundes, E.M.,Vangamudi, B.,Camper, D.V.,Kuznetsov, A.G.,Browning, C.F.,Feldkamp, M.D.,Frank, A.O.,Gilston, B.A.,Olejniczak, E.T.,Rossanese, O.W.,Waterson, A.G.,Chazin, W.J.,Fesik, S.W.; Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A.; Chemmedchem, 11:893-899, 2016; PubMed: 26748787; DOI: 10.1002/cmdc.201500479

実験手法

X-RAY DIFFRACTION (1.21 Å)