5E6T

Crystal structure of bovine norovirus P domain

5E6T の概要

• エントリーDOI: 10.2210/pdb5e6t/pdb
• 分子名称: Capsid, ZINC ION (3 entities in total)
• 機能のキーワード: viral protein, protruding domain
• 由来する生物種: Norovirus Bo/GIII/B309/2003/BEL
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63237.56

構造登録者

Singh, B.K.,Hansman, G.S. (登録日: 2015-10-10, 公開日: 2015-12-09, 最終更新日: 2024-01-10)

主引用文献

Singh, B.K.,Koromyslova, A.,Hansman, G.S.
Structural analysis of bovine norovirus protruding domain.
Virology, 487:296-301, 2015

PubMed Abstract: We determined a structure of a bovine (genogroup III, GIII) norovirus capsid protruding (P) domain using X-ray crystallography. The bovine P domain was reminiscent of other norovirus genogroups (GI, GII, GIV, and GV), but closely matched the human GI P domain. We also identified a monoclonal antibody that was capable of binding the five different (GI-GV) P domains. Our data suggests that genetically diverse noroviruses still contain common epitopes.

PubMed: 26599362
DOI: 10.1016/j.virol.2015.10.022

実験手法

X-RAY DIFFRACTION (2.27 Å)