5E5X

Structure of the amyloid forming peptide ANFLVH (residues 13-18) from islet amyloid polypeptide

5E5X の概要

• エントリーDOI: 10.2210/pdb5e5x/pdb
• 関連するPDBエントリー: 5E5V 5E5Z 5E61
• 分子名称: ANFLVH (residues 13-18) from islet amyloid polypeptide (1 entity in total)
• 機能のキーワード: amyloid proto-fibril, protein fibril, de novo protein, membrane protein
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 700.80

構造登録者

Soriaga, A.B.,Eisenberg, D. (登録日: 2015-10-09, 公開日: 2015-12-16, 最終更新日: 2024-03-06)

主引用文献

Soriaga, A.B.,Sangwan, S.,Macdonald, R.,Sawaya, M.R.,Eisenberg, D.
Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets.
J.Phys.Chem.B, 120:5810-5816, 2016

PubMed Abstract: Structural studies of amyloidogenic segments by X-ray crystallography have revealed a novel packing motif, consisting of out-of-register β sheets, which may constitute one of the toxic species in aggregation related diseases. Here we sought to determine the presence of such a motif in islet amyloid polypeptide (IAPP), whose amyloidogenic properties are associated with type 2 diabetes. We determined four new crystal structures of segments within IAPP, all forming steric zippers. Most interestingly, one of the segments in the fibril core of IAPP forms an out-of-register steric zipper. Analysis of this structure reveals several commonalities with previously solved out-of-register fibrils. Our results provide additional evidence of out-of-register β sheets as a common structural motif in amyloid aggregates.

PubMed: 26629790
DOI: 10.1021/acs.jpcb.5b09981

実験手法

X-RAY DIFFRACTION (1.61 Å)