5E27

The structure of Resuscitation Promoting Factor B from M. tuberculosis reveals unexpected ubiquitin-like domains

5E27 の概要

• エントリーDOI: 10.2210/pdb5e27/pdb
• 分子名称: Resuscitation-promoting factor RpfB (2 entities in total)
• 機能のキーワード: cell wall, peptidoglycan, tuberculosis, cell adhesion
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51806.61

構造登録者

Ruggiero, A.,Squeglia, F.,Romano, M.,Vitagliano, L.,De Simone, A.,Berisio, R. (登録日: 2015-09-30, 公開日: 2015-11-18, 最終更新日: 2024-11-06)

主引用文献

Ruggiero, A.,Squeglia, F.,Romano, M.,Vitagliano, L.,De Simone, A.,Berisio, R.
The structure of Resuscitation promoting factor B from M. tuberculosis reveals unexpected ubiquitin-like domains.
Biochim.Biophys.Acta, 1860:445-451, 2015

PubMed Abstract: RpfB is a key factor in resuscitation from dormancy of Mycobacterium tuberculosis. This protein is a cell-wall glycosidase, which cleaves cell-wall peptidoglycan. RpfB is structurally complex and is composed of three types of domains, including a catalytic, a G5 and three DUF348 domains. Structural information is currently limited to a portion of the protein including only the catalytic and G5 domains. To gain insights into the structure and function of all domains we have undertaken structural investigations on a large protein fragment containing all three types of domains that constitute RpfB (RpfB3D).

PubMed: 26549874
DOI: 10.1016/j.bbagen.2015.11.001

実験手法

X-RAY DIFFRACTION (2.6 Å)