5E16

Co-crystal structure of the N-termial cGMP binding domain of Plasmodium falciparum PKG with cGMP

Summary for 5E16

Entry DOI	10.2210/pdb5e16/pdb
Descriptor	CGMP-dependent protein kinase, CYCLIC GUANOSINE MONOPHOSPHATE (3 entities in total)
Functional Keywords	kinase, cgmp binding domain, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Plasmodium falciparum
Total number of polymer chains	1
Total formula weight	16423.28
Authors	El Bakkouri, M.,Walker, J.R.,Loppnau, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Hui, R.,Structural Genomics Consortium (SGC) (deposition date: 2015-09-29, release date: 2015-11-04, Last modification date: 2023-09-27)
Primary citation	El Bakkouri, M.,Kouidmi, I.,Wernimont, A.K.,Amani, M.,Hutchinson, A.,Loppnau, P.,Kim, J.J.,Flueck, C.,Walker, J.R.,Seitova, A.,Senisterra, G.,Kakihara, Y.,Kim, C.,Blackman, M.J.,Calmettes, C.,Baker, D.A.,Hui, R. Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proc.Natl.Acad.Sci.USA, 116:14164-14173, 2019 Cited by PubMed: 31239348 DOI: 10.1073/pnas.1905558116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation