5E16

Co-crystal structure of the N-termial cGMP binding domain of Plasmodium falciparum PKG with cGMP

5E16 の概要

• エントリーDOI: 10.2210/pdb5e16/pdb
• 分子名称: CGMP-dependent protein kinase, CYCLIC GUANOSINE MONOPHOSPHATE (3 entities in total)
• 機能のキーワード: kinase, cgmp binding domain, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16423.28

構造登録者

El Bakkouri, M.,Walker, J.R.,Loppnau, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Hui, R.,Structural Genomics Consortium (SGC) (登録日: 2015-09-29, 公開日: 2015-11-04, 最終更新日: 2023-09-27)

• 主引用文献: El Bakkouri, M.,Kouidmi, I.,Wernimont, A.K.,Amani, M.,Hutchinson, A.,Loppnau, P.,Kim, J.J.,Flueck, C.,Walker, J.R.,Seitova, A.,Senisterra, G.,Kakihara, Y.,Kim, C.,Blackman, M.J.,Calmettes, C.,Baker, D.A.,Hui, R.; Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.; Proc.Natl.Acad.Sci.USA, 116:14164-14173, 2019; PubMed: 31239348; DOI: 10.1073/pnas.1905558116

実験手法

X-RAY DIFFRACTION (1.65 Å)