5DYK

Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum - Apo form

Replaces:  4MYJ

Summary for 5DYK

• Entry DOI: 10.2210/pdb5dyk/pdb
• Related: 4MYJ
• Descriptor: CGMP-dependent protein kinase, 1,2-ETHANEDIOL, SULFATE ION, ... (5 entities in total)
• Functional Keywords: transferase, kinase, structural genomics, structural genomics consortium, sgc
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 1
• Total formula weight: 98315.01

Authors

Wernimont, A.K.,Tempel, W.,He, H.,Seitova, A.,Hills, T.,Neculai, A.M.,Baker, D.A.,Flueck, C.,Kettleborough, C.A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Hui, R.,Hutchinson, A.,El Bakkouri, M.,Structural Genomics Consortium (SGC) (deposition date: 2015-09-24, release date: 2015-11-04, Last modification date: 2023-09-27)

• Primary citation: El Bakkouri, M.,Kouidmi, I.,Wernimont, A.K.,Amani, M.,Hutchinson, A.,Loppnau, P.,Kim, J.J.,Flueck, C.,Walker, J.R.,Seitova, A.,Senisterra, G.,Kakihara, Y.,Kim, C.,Blackman, M.J.,Calmettes, C.,Baker, D.A.,Hui, R.; Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.; Proc.Natl.Acad.Sci.USA, 116:14164-14173, 2019; PubMed: 31239348; DOI: 10.1073/pnas.1905558116

Experimental method

X-RAY DIFFRACTION (2.45 Å)