5DX3

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P3 and Estradiol

5DX3 の概要

• エントリーDOI: 10.2210/pdb5dx3/pdb
• 分子名称: Estrogen receptor, Stapled Peptide SRC2-P3, ESTRADIOL, ... (6 entities in total)
• 機能のキーワード: synthetic peptide, stapled peptide, estrogen receptor alpha, somatic mutation, peptide mimetic, af-2 binding, hormone receptor-peptide complex, hormone receptor/peptide
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 63015.98

構造登録者

Speltz, T.E.,Fanning, S.W.,Mayne, C.G.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W. (登録日: 2015-09-23, 公開日: 2016-07-20, 最終更新日: 2023-11-15)

• 主引用文献: Speltz, T.E.,Fanning, S.W.,Mayne, C.G.,Fowler, C.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W.; Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.; Angew.Chem.Int.Ed.Engl., 55:4252-4255, 2016; PubMed: 26928945; DOI: 10.1002/anie.201510557

実験手法

X-RAY DIFFRACTION (2.0903 Å)