5DW0

TrpB from Pyrococcus furiosus with L-serine bound as the external aldimine

Summary for 5DW0

• Entry DOI: 10.2210/pdb5dw0/pdb
• Related: 5DVZ 5DW3 5E0K
• Descriptor: Tryptophan synthase beta chain 1, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE, SODIUM ION, ... (4 entities in total)
• Functional Keywords: plp, external aldimine, pr, lyase
• Biological source: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
• Total number of polymer chains: 4
• Total formula weight: 176064.60

Authors

Buller, A.R.,Arnold, F.H. (deposition date: 2015-09-22, release date: 2015-11-11, Last modification date: 2024-03-06)

• Primary citation: Buller, A.R.,Brinkmann-Chen, S.,Romney, D.K.,Herger, M.,Murciano-Calles, J.,Arnold, F.H.; Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation.; Proc.Natl.Acad.Sci.USA, 112:14599-14604, 2015; PubMed: 26553994; DOI: 10.1073/pnas.1516401112

Experimental method

X-RAY DIFFRACTION (2.01 Å)