5DTQ

Crystal structure of Dot1L in complex with inhibitor CPD3 [(2,6-dichlorophenyl)(quinolin-6-yl)methanone]

5DTQ の概要

• エントリーDOI: 10.2210/pdb5dtq/pdb
• 分子名称: Histone-lysine N-methyltransferase, H3 lysine-79 specific, (2,6-dichlorophenyl)(quinolin-6-yl)methanone (3 entities in total)
• 機能のキーワード: inhibitor, complex, methyltransferase, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q8TEK3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77517.50

構造登録者

Scheufler, C.,Be, C.,Moebitz, H.,Stauffer, F. (登録日: 2015-09-18, 公開日: 2016-06-15, 最終更新日: 2024-01-10)

• 主引用文献: Scheufler, C.,Mobitz, H.,Gaul, C.,Ragot, C.,Be, C.,Fernandez, C.,Beyer, K.S.,Tiedt, R.,Stauffer, F.; Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket.; Acs Med.Chem.Lett., 7:730-734, 2016; PubMed: 27563394; DOI: 10.1021/acsmedchemlett.6b00168

実験手法

X-RAY DIFFRACTION (2.61 Å)