5DR6

Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122

5DR6 の概要

• エントリーDOI: 10.2210/pdb5dr6/pdb
• 分子名称: Aurora kinase A, 2-(3-bromophenyl)quinoline-4-carboxylic acid, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, ... (4 entities in total)
• 機能のキーワード: aurora a kinase, mitotic kinase, ppi, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32530.04

構造登録者

Janecek, M.,Rossmann, M.,Sharma, P.,Emery, A.,McKenzie, G.J.,Huggins, D.J.,Stockwell, S.,Stokes, J.A.,Almeida, E.G.,Hardwick, B.,Narvaez, A.J.,Hyvonen, M.,Spring, D.R.,Venkitaraman, A.R. (登録日: 2015-09-15, 公開日: 2016-07-20, 最終更新日: 2024-01-10)

• 主引用文献: Janecek, M.,Rossmann, M.,Sharma, P.,Emery, A.,Huggins, D.J.,Stockwell, S.R.,Stokes, J.E.,Tan, Y.S.,Almeida, E.G.,Hardwick, B.,Narvaez, A.J.,Hyvonen, M.,Spring, D.R.,McKenzie, G.J.,Venkitaraman, A.R.; Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.; Sci Rep, 6:28528-28528, 2016; PubMed: 27339427; DOI: 10.1038/srep28528

実験手法

X-RAY DIFFRACTION (2.534 Å)