5DPV
Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122
Summary for 5DPV
Entry DOI | 10.2210/pdb5dpv/pdb |
Descriptor | Aurora kinase A, 2-(3-bromophenyl)-8-fluoroquinoline-4-carboxylic acid, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | aurora a kinase, mitotic kinase, ppi, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 |
Total number of polymer chains | 1 |
Total formula weight | 32548.04 |
Authors | Janecek, M.,Rossmann, M.,Sharma, P.,Emery, A.,McKenzie, G.J.,Huggins, D.J.,Stockwell, S.,Stokes, J.A.,Almeida, E.G.,Hardwick, B.,Narvaez, A.J.,Hyvonen, M.,Spring, D.R.,Venkitaraman, A.R. (deposition date: 2015-09-14, release date: 2016-07-20, Last modification date: 2024-01-10) |
Primary citation | Janecek, M.,Rossmann, M.,Sharma, P.,Emery, A.,Huggins, D.J.,Stockwell, S.R.,Stokes, J.E.,Tan, Y.S.,Almeida, E.G.,Hardwick, B.,Narvaez, A.J.,Hyvonen, M.,Spring, D.R.,McKenzie, G.J.,Venkitaraman, A.R. Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep, 6:28528-28528, 2016 Cited by PubMed: 27339427DOI: 10.1038/srep28528 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.285 Å) |
Structure validation
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