5DP9

Crystal Structure of EV71 3C Proteinase in complex with compound 9

Summary for 5DP9

• Entry DOI: 10.2210/pdb5dp9/pdb
• Related: 5DP3 5DP4 5DP5 5DP6 5DP7 5DP8 5DPA
• Descriptor: 3C proteinase, ethyl (2Z,4S)-4-[(N-{[(cyclobutylmethyl)amino](oxo)acetyl}-L-phenylalanyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate (3 entities in total)
• Functional Keywords: hand, foot and mouth disease, 3c proteinase, peptidomimetics, drug design, rupintrivir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Enterovirus A71
• Cellular location: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Virion : A9XG43
• Total number of polymer chains: 1
• Total formula weight: 21904.08

Authors

Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Li, N.,Cai, Y.,Li, J.,Lin, T. (deposition date: 2015-09-12, release date: 2016-03-30, Last modification date: 2023-11-08)

• Primary citation: Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T.; Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71; Biochim.Biophys.Acta, 1860:1299-1307, 2016; PubMed: 26987809; DOI: 10.1016/j.bbagen.2016.03.017

Experimental method

X-RAY DIFFRACTION (1.9 Å)