5DP8

Crystal Structure of EV71 3C Proteinase in complex with compound 8

5DP8 の概要

• エントリーDOI: 10.2210/pdb5dp8/pdb
• 関連するPDBエントリー: 5DP3 5DP4 5DP5 5DP6 5DP7 5DP9 5DPA
• 分子名称: 3C proteinase, ethyl (2Z,4S)-4-[(N-{[(2-cyclopropylethyl)amino](oxo)acetyl}-L-phenylalanyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate (3 entities in total)
• 機能のキーワード: hand, foot and mouth disease, 3c proteinase, peptidomimetics, drug design, rupintrivir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Enterovirus A71
• 細胞内の位置: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Virion : A9XG43
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21904.08

構造登録者

Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Li, N.,Cai, Y.,Li, J.,Lin, T. (登録日: 2015-09-12, 公開日: 2016-03-30, 最終更新日: 2024-11-06)

主引用文献

Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T.
Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71
Biochim.Biophys.Acta, 1860:1299-1307, 2016

PubMed Abstract: Enterovirus 71 (EV71) is a causative agent of hand, foot and mouth disease (HFMD), which can spread its infection to central nervous and other systems with severe consequence. A key factor in the replication of EV71 is its 3C proteinase (3C(pro)), a significant drug target. Peptidomimetics were employed as inhibitors of this enzyme for developing antivirals. However, the peptide bonds in these peptidomimetics are a source of low bioavailability due to their susceptibility to protease digestion. To produce non-peptidomimetic inhibitors by replacing these peptide bonds, it would be important to gain better understanding on the contribution of each component to the interaction and potency.

PubMed: 26987809
DOI: 10.1016/j.bbagen.2016.03.017

実験手法

X-RAY DIFFRACTION (2.4 Å)