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5DP5

Crystal Structure of EV71 3C Proteinase in complex with compound 4

Summary for 5DP5
Entry DOI10.2210/pdb5dp5/pdb
Related5DP3 5DP4 5DP6 5DP7 5DP8 5DP9 5DPA
Descriptor3C proteinase, ethyl (2Z,4S)-4-{[(2R,5S)-5-amino-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanoyl]amino}-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate (3 entities in total)
Functional Keywordshand, foot and mouth disease, 3c proteinase, peptidomimetics, drug design, rupintrivir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceEnterovirus A71
Cellular locationHost cytoplasm : A9XG43
Total number of polymer chains1
Total formula weight20465.59
Authors
Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Li, N.,Cai, Y.,Li, J.,Lin, T. (deposition date: 2015-09-12, release date: 2016-03-30, Last modification date: 2016-04-06)
Primary citationWu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T.
Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71
Biochim.Biophys.Acta, 1860:1299-1307, 2016
Cited by
PubMed: 26987809
DOI: 10.1016/j.bbagen.2016.03.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.03 Å)
Structure validation

217705

数据于2024-03-27公开中

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