5DOT
Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form
Summary for 5DOT
Entry DOI | 10.2210/pdb5dot/pdb |
Descriptor | Carbamoyl-phosphate synthase [ammonia], mitochondrial, NICKEL (II) ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | carbamoyl phosphate synthase (ammonia utilizing), carbamoyl phosphate, ammonia, n-acetyl-l-glutamate, adenosine triphosphate, apo, urea cycle, ligase, multi-domain, allosteric site, rare disease, cps1 deficiency, hyperammonemia |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion : P31327 |
Total number of polymer chains | 2 |
Total formula weight | 328919.70 |
Authors | Polo, L.M.,de Cima, S.,Fita, I.,Rubio, V. (deposition date: 2015-09-11, release date: 2015-12-09, Last modification date: 2024-01-10) |
Primary citation | de Cima, S.,Polo, L.M.,Diez-Fernandez, C.,Martinez, A.I.,Cervera, J.,Fita, I.,Rubio, V. Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5:16950-16950, 2015 Cited by PubMed: 26592762DOI: 10.1038/srep16950 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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