5DOT

Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form

5DOT の概要

• エントリーDOI: 10.2210/pdb5dot/pdb
• 分子名称: Carbamoyl-phosphate synthase [ammonia], mitochondrial, NICKEL (II) ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: carbamoyl phosphate synthase (ammonia utilizing), carbamoyl phosphate, ammonia, n-acetyl-l-glutamate, adenosine triphosphate, apo, urea cycle, ligase, multi-domain, allosteric site, rare disease, cps1 deficiency, hyperammonemia
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion : P31327
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 328919.70

構造登録者

Polo, L.M.,de Cima, S.,Fita, I.,Rubio, V. (登録日: 2015-09-11, 公開日: 2015-12-09, 最終更新日: 2024-01-10)

• 主引用文献: de Cima, S.,Polo, L.M.,Diez-Fernandez, C.,Martinez, A.I.,Cervera, J.,Fita, I.,Rubio, V.; Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.; Sci Rep, 5:16950-16950, 2015; PubMed: 26592762; DOI: 10.1038/srep16950

実験手法

X-RAY DIFFRACTION (2.4 Å)